One word, innovation, encapsulates much of the very essence of Israel. While an ingrained culture of challenging rules and regulations can be problematic in many realms, it is a fundamental ingredient underlying the country’s disproportional international leadership in scientific and technological breakthroughs. Israel has one of the highest number of Nobel laureates in the sciences per capita in this millennium, while the number of international patents produced by its citizens, relative to its size, places the country among the world’s elite. Broad recognition of this leadership has led to extensive foreign direct investment in Israel. It places the country, together with the United States, in a league of their own when it comes to venture capital investments that are nearly off the chart in comparison with all other countries.